Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Graves’ Disease Following Immune Reconstitution or Immunomodulatory Treatment: Should We Manage it any Differently?
source: Clinical Endocrinology
year: 2014
authors: Weetman AP
summary/abstract:Graves’ disease and other disorders of thyroid function may occur following treatment with novel anticancer agents or during periods of lymphocyte recovery after lymphopenia. There are three main settings for such lymphocyte reconstitution: recovery after a bone marrow or haematopoietic stem cell transplant, alemtuzumab treatment and the use of highly active antiretroviral therapy (HAART) for human immunodeficiency virus infection.
The available evidence suggests that Graves’ disease behaves as normal in most of these cases and should be treated conventionally, but it may follow a more favourable course in those receiving alemtuzumab or HAART. As spontaneous or drug-induced remission may be more likely in these two settings, first-line treatment should usually consist of an antithyroid drug.
organization: University of Sheffield, UKDOI: 10.1111/cen.12427
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