Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Pediatric Graves’ Disease: Controversies in Management
source: Hormone Research in Pædiatrics
year: 2010
authors: Rivkees SA
summary/abstract:Background/Aims:
Graves’ disease (GD) is the most common cause of thyrotoxicosis in children and adolescents. Caused by immunologic stimulation of the thyroid-stimulating hormone receptor, lasting remission occurs in only a minority of pediatric patients with GD, including children treated with antithyroid drugs (ATDs) for many years. Thus the majority of pediatric patients with GD will need thyroidectomy or treatment with radioactive iodine (RAI; (131) I).
Results:
When ATDs are used in children, only methimazole should be used. Propylthiouracil is associated with an unacceptable risk of severe liver injury in children and should never be used as first-line therapy. If remission (defined as normal thyroid function off ATDs) is not achieved after 1 or 2 years of ATD therapy, (131) I or surgery may be considered, with the choice influenced by the age of the individual. When (131) I is used, administered doses should be >150 μCi/g of thyroid tissue. When surgery is performed, near total or total thyroidectomy is recommended.
Conclusion:
Choosing a treatment approach for childhood GD is often a difficult and highly personal decision. Discussion of the advantages and risks of each therapeutic option is essential to help the patient and family select a treatment option.
DOI: 10.1159/000320028
read more full text
myBinderRelated Content
-
ENFOQUE en la salud ocularhttps://www.onegravesvoice.com/wp-conten...
-
Early Experience With Teprotumumab for Chronic Thyroid Eye DiseasePurpose: To report the first case of a ...
-
A Prospective Study of the Effects of Radioiodine Therapy for Hyperthyroidism in Patients With Minimally Active Grav...Context: Radioiodine is an effective an...
-
Long-Term Outcomes of Orbital Fat Decompression in Graves’ OrbitopathyPurpose: To evaluate the long-term clin...
-
Hyperthyroid Patients Without Graves’ Orbitopathy are not at Increased Risk of Developing Glaucoma: A Nationwi...Purpose: Graves' disease (GD) and toxic...
-
Ted’s Thyroid Eye Disease Journey – Dr. Raymond Douglashttps://www.youtube.com/watch?v=6rFNwbIh...
-
Mortality in Graves’ Orbitopathy is Increased and Influenced By Gender, Age and Pre-Existing Morbidity: A Nati...Introduction: It is unclear whether the...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Google