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Patients with Graves’ disease who carry a specific gene show a more than seven-times increased risk of relapse after treatment, suggesting a potentially reliable and important biomarker in management of the disease.
There is a high risk of relapse in Graves’ disease, but there are currently no biomarkers proven to be predictors of relapse; the latter could be essential in disease management decision-making, a coauthor of the research explained.
“The risk of relapse in Graves’ disease is quite high — around 40% to 50% in Europe, and 70% to 80% in the United States,” said Masanobu Yamada, MD, PhD, of the Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan, in a press statement by Thyroid.
“Our finding may give us a tool to find at-risk patients at an earlier stage and more effectively tailor their treatment options,” said Dr Yamada.
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