Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Graves’ Orbitopathy
source: Family Practice Notebook
year: 2021
summary/abstract:Epidemiology:
Eye complications occur in 25-50% of Grave’s disease.
Pathophysiology:
Grave’s disease induced eye changes:
• Sensitized orbital tissue-specific T-Lymphocytes
• Local inflammatory cellular infiltration of eye
Orbital fibroblasts mediate changes:
• Adipose hypertrophy
• Glycosaminoglycan accumulates
Residual scarring may cause irreversible proptosis.
Risk Factors:
Tobacco abuse (Relative Risk 3.7)
Older men appear to have more severe cases
Radioiodine therapy may cause flare in eye disease
• Prednisone used to prevent flare
– Dose: 40 to 80 mg daily
– Taper off over 3 months.
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