source: Family Practice Notebook summary/abstract:
Eye complications occur in 25-50% of Grave’s disease.
Grave’s disease induced eye changes:
• Sensitized orbital tissue-specific T-Lymphocytes
• Local inflammatory cellular infiltration of eye
Orbital fibroblasts mediate changes:
• Adipose hypertrophy
• Glycosaminoglycan accumulates
Residual scarring may cause irreversible proptosis.
Tobacco abuse (Relative Risk 3.7)
Older men appear to have more severe cases
Radioiodine therapy may cause flare in eye disease
• Prednisone used to prevent flare
– Dose: 40 to 80 mg daily
– Taper off over 3 months.