Graves' Orbitopathy | oneGRAVESvoice
Global Search
Global Search

Trusted Resources: Evidence & Education

Scientific literature and patient education texts

Back to Evidence & Education / Reference Materials

Graves’ Orbitopathy

key information

source: Family Practice Notebook

year: 2021

summary/abstract:

Epidemiology:
Eye complications occur in 25-50% of Grave’s disease.

Pathophysiology:
Grave’s disease induced eye changes:

   • Sensitized orbital tissue-specific T-Lymphocytes

   • Local inflammatory cellular infiltration of eye

Orbital fibroblasts mediate changes:

   • Adipose hypertrophy

   • Glycosaminoglycan accumulates

Residual scarring may cause irreversible proptosis.

Risk Factors:
Tobacco abuse (Relative Risk 3.7)

Older men appear to have more severe cases

Radioiodine therapy may cause flare in eye disease

   • Prednisone used to prevent flare

    – Dose: 40 to 80 mg daily

    – Taper off over 3 months.

 

read more

Related Content

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close

Powered by

Brought to you by

Supported through an independent
educational grant by

© 2022 rareLife solutions Inc.