Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Impaired Immune Regulation After Radioiodine Therapy for Graves’ Disease and the Protective Effect of Methimazole
source: Endocrine
year: 2016
authors: Côté-Bigras S, Tran V, Turcotte S, Rola-Pleszczynski M, Verreault J, Rottembourg D
summary/abstract:Both therapies for Graves’ disease (GD), radioactive iodine (RAI) and antithyroid drugs (ATD), were reported to have specific immune effects. We aimed at investigating the effects of RAI therapy on cellular subsets involved in immune regulation.
We conducted a thirty day follow-up prospective cohort study of adult patients. Patients eligible for RAI therapy at our centre were approached. Twenty seven patients with GD were recruited, among whom 11 were treated with ATD. Twenty-two healthy subjects (HS) were also studied. Over time, frequency of regulatory T cells (Treg) and of invariant natural killer T cells (iNKT), along with Treg cell-mediated suppression and underlying mechanisms, were monitored in the peripheral blood. Variance in frequency of Treg and iNKT after RAI therapy was higher in GD patients than in HS over time (p < 0.0001). Reduced Treg suppressive function was observed after RAI therapy in GD patients (p = 0.002). ATD medication prior to RAI dampened these outcomes: less variation of Treg frequency (p = 0.0394), a trend toward less impaired Treg function, and prevention of reduced levels of suppressive cytokines (p < 0.05).
Shortly after RAI therapy, alterations in immunoregulatory cells in patients with GD were observed and partially prevented by an ATD pretreatment. Worsening of autoimmunity after RAI was explained in previous studies by enhanced immune activity. This study adds new highlights on immune regulation deficiencies after therapeutic interventions in thyroid autoimmunity.
organization: Sherbrooke University Hospital and Faculty of Medicine, CanadaDOI: 10.1007/s12020-015-0832-2
read more
myBinderRelated Content
-
...Hyperthyroidism is caused when the thyro...
-
Radioiodine Therapy for HyperthyroidismA 37-year-old woman receives a diagnosis...
-
Radioiodine-Associated Exacerbation of Graves’ Orbitopathy in the Japanese Population: Randomized Prospective ...Context: Exacerbation of Graves' orbito...
-
Stress Triggers the Onset and the Recurrences of Hyperthyroidism in Patients With Graves’ DiseaseThe aim of this study was to evaluate th...
-
TSH-Receptor Autoimmunity in Graves’ Disease After Therapy With Anti-Thyroid Drugs, Surgery, or Radioiodine: A...Introduction: Autoimmunity against the ...
-
Cancer Mortality Following Treatment for Adult HyperthyroidismContext: High-dose iodine 131 is the tr...
-
Comparative Analysis of Radioactive Iodine Versus Thyroidectomy for Definitive Treatment of Graves’ DiseaseBackground: Management of Graves diseas...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Google