Is the Heart Involvement in Graves’ Disease Actually an Autoimmune Effect in Some Patients? Report From Cogthy – A Prospective, Longitudinal Case-Controlled Study - oneGRAVESvoice
Global Search
Global Search

Trusted Resources: Evidence & Education

Scientific literature and patient education texts

Back to Evidence & Education / Abstracts & Posters

Is the Heart Involvement in Graves’ Disease Actually an Autoimmune Effect in Some Patients? Report From Cogthy – A Prospective, Longitudinal Case-Controlled Study

key information

source: Thyroid

year: 2018

authors: K. Tammelin, M. Holmberg, A. Lundgren, H. Filipsson Nystrom

summary/abstract:

In Graves’ disease (GD), hyperthyroidism per se may entail tachyarrhythmia, atrial fibrillation and heart failure. Known GD complications are, however, of autoimmune origin.

In GD patients with heart complications, stimulatory autoantibodies targeting the cardiovascular system (CardAbs) are frequent. Although previous studies were relatively small and used non-standardized methods, we hypothesize that CardAbs are frequent in GD in general and affect heart function.

We used standardized ELISA assays to determine if CardAbs 1) were more frequent in hyperthyroid GD patients than controls, 2) were influenced by antithyroid drugs (ATD), 3) correlate with heart related symptoms or biomarkers. Our preliminary data with higher beta1 adrenergic receptor antibody (anti-B1) levels in GD that decreased after ATD strengthen our hypotheses. Premenopausal women (n = 60) with FT4 > 50 pmol/L (ref 12-22) were evaluated at diagnosis and after 7.5 months for CardAbs (anti-B1, muscarinic type 2 receptor (anti-M2) and angiotensin II type 1 receptor (anti-AT1) antibodies), symptom score, NTproBNP (marker of heart failure) and Troponine-I (TNI, marker of cardiac myocyte damage).

organization: Sahlgrenska University Hospital, Sweden; Institution of medicine, Sweden; Karolinska University Hospital, Sweden

read more

Related Content

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close

Powered by

© 2022 rareLife solutions Inc.