Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Meta-Analysis of Methylprednisolone Pulse Therapy for Graves’ Ophthalmopathy
source: Clinical & Experimental Ophthalmology
year: 2014
authors: Gao G, Dai J, Qian Y, Ma F
summary/abstract:A meta-analysis was performed to evaluate the efficacy of methylprednisolone pulse therapy for Graves’ ophthalmopathy. Eight studies involving 376 patients were included. A higher effective rate was found for patients treated with intravenous glucocorticoids (IVGC) over oral glucocorticoids (OGC) (risk ratio [RR] = 1.48; 95% confidence interval [CI] = 1.18-1.86). The combined IVGC and orbital radiotherapy (OR) was markedly more effective than OGC+OR (RR = 1.40; 95% CI = 1.11-1.77). IVGC resulted in an obvious reduction of clinical activity score (CAS) compared with OGC, with a weighted mean difference (WMD) of 0.86 (95% CI = 0.53-1.18). The WMD for the reduction of the CAS between IVGC+OR and OGC+OR was 0.66 (95% CI = 0.30-1.02).
IVGC is an effective treatment and cause fewer adverse events. Limiting the total cumulative dose of methylprednisolone, careful patient selection and monitoring the condition of patients during treatment are necessary.
organization: Eye and ENT Hospital Affiliated with Fudan University, China; Ministry of Health PR China, ChinaDOI: 10.1111/ceo.12317
read more full text
Related Content
-
Shannath Louise Merbs, MD, PhD, FACSShannath Louise Merbs is a fellowship-tr...
-
“TED Today” Episode 2https://www.facebook.com/111185326929227...
-
Protect Your Eyes: A Baseball Player’s StoryThyroid eye disease, also known as Grave...
-
Review of the Literature and Report of a Large Series of Patients Regarding the Association of Other Autoimmune Dise...Several studies have reported an associa...
-
Advances in the Pharmacological Treatment of Graves’ OrbitopathyGraves' orbitopathy has a deteriorating ...
-
Hyperthyroid Patients Without Graves’ Orbitopathy are not at Increased Risk of Developing Glaucoma: A Nationwi...Purpose: Graves' disease (GD) and toxic...
-
National Survey for Those Living With Thyroid Eye Disease (TED)Horizon Therapeutics is conducting a nat...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.