Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Risk Factors for Graves’ Orbitopathy; the Australian Thyroid-Associated Orbitopathy Research (ATOR) Study.
source: The Journal of Clinical Endocrinology & Metabolism
year: 2016
authors: Khong JJ, Finch S, De Silva C, Rylander S, Craig JE, Selva D, Ebeling PR
summary/abstract:Context:
Previous association studies suggest the development of Graves’ orbitopathy (GO) is variably influenced by environmental risk factors.
Objective:
To determine the risk factors and predict odds for developing GO in Graves’ hyperthyroidism (GH).
Design:
Case-control study.
Setting:
Multi-centre Australian Thyroid-associated Orbitopathy Research group consisting of tertiary endocrinology and ophthalmology outpatients and related private practices.
Patients or Other Participants:
A total of 1042 participants with GH were designated as cases if they had GO (n = 604) and controls if they did not have GO (n = 438).
Main Outcome Measures:
Primary outcome was GO risk factors and secondary outcome was dysthyroid optic neuropathy (DON) with the effects of risk factors measured by odds ratio (OR) using multiple logistic regression, adjusted for known risk factors and exploratory variables.
Results:
The odds of GO increased by 17% for each decade increase in the age of onset of GH (OR 1.17, confidence interval (CI): 1.06-1.29; P = .002) and by 7% for each year increase in the duration of GH (OR 1.07, CI: 1.05-1.10; P < .001). Smoking increased the odds for GO by 2.22 for current smoker and 2.07 for exsmoker (P < .001), compared with never smoking. The odds of GO are 86% less in Graves’ patients using antithyroid medication than those not (OR 0.14, CI: 0.06-0.34; P < .001). Predictors for DON were older age, oculomotility restriction, strabismus, reduced palpebral aperture, and active GO.
Conclusions:
This study identified increase age of onset, duration of GH, and smoking as risk factors for GO. Usage of antithyroid medication was negatively related to GO. Older patients with restricted ocular motility, strabismus, and active GO are at higher risk of DON and may benefit from early medical intervention.
DOI: 10.1210/jc.2015-4294
read more full text
Related Content
-
Efficacy of B-cell Targeted Therapy With Rituximab in Patients With Active Moderate to Severe Graves’ Orbitopa...Background: Preliminary studies have sh...
-
Review of the Literature and Report of a Large Series of Patients Regarding the Association of Other Autoimmune Dise...Several studies have reported an associa...
-
FDA Committee Unanimously Recommends Approval of Teprotumumab for Thyroid Eye DiseaseThe Dermatologic and Ophthalmic Drugs Ad...
-
Ask a Doctor questions about Graves’ disease, thyroid eye disease, & Hashimoto’s thyroiditishttps://www.youtube.com/watch?v=RxElrnS6...
-
Gut Microbes May Play Role in Graves ’ Disease Diagnosis, Thyroid AutoimmunityThe abundance and diversity of intestina...
-
People Under 30: How to get or Stay on a Parent’s Health Insurance PlanIf a parent’s health insurance plan co...
-
Collin M. Mcclelland, MDCollin M. Mcclelland is an Associate Pro...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.