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The United States Food and Drug Administration (FDA) has added a Boxed Warning to the label for propylthiouracil, a drug used to treat hyperthyroidism (overactive thyroid), to include information about reports of severe liver injury and acute liver failure, some of which have been fatal, in adult and pediatric patients using this medication.
The new warning also states that for patients being started on treatment for hyperthyroidism it may be appropriate to reserve use of propylthiouracil for those who cannot tolerate other treatments such as methimazole, radioactive iodine or surgery. In addition, due to the occurrence of birth defects that have been observed with the use of methimazole during the first trimester of pregnancy, propylthiouracil may be the treatment of choice during and just before the first trimester of pregnancy.
Evidence & EducationHepatic Dysfunction Related to Thyrotropin Receptor Antibody in Patients With Graves’ DiseaseBackground: Hepatic dysfunction is a co...
Evidence & EducationSuccessful Re-Administration of Low-Dose of Methimazole (MMI) in Graves’ Disease Patients who Experienced Alle...Objective: When patients with Graves' d...
Evidence & EducationRisk Factors of Hepatic Dysfunction in Patients With Graves’ Hyperthyroidism and the Efficacy of 131iodine Tre...Hepatic dysfunction is often observed in...
Evidence & EducationRadioiodine Therapy Versus Antithyroid Medications for Graves’ DiseaseBackground: Graves' disease is the most...
People & PlacesUniversity of Utah Health – Thyroid & Parathyroid ClinicThe Thyroid & Parathyroid Clinic at ...
Evidence & EducationThyroid Eye DisordersWhat is the Thyroid? The thyroid is a b...
Videos & VisualsGraves’ Disease: What Were Your Symptoms?https://www.youtube.com/watch?v=0WrxPDQV...
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