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The treatment of Graves’ disease with the antithyroid drug methimazole is associated with a significantly increased risk of acute pancreatitis, and although cases are rare, the risk justifies warnings about this potential adverse event, according to a nationwide controlled study in Denmark spanning more than 20 years.
“The data are very strong and convincing, (showing) that the risk of pancreatitis is of the same order as that of agranulocytosis, which we have warned against and informed about for decades,” first author Laszlo Hegedus, MD, president of the European Thyroid Association, told Medscape Medical News.
“So not taking this seriously would be extremely arrogant,” he said after presenting his findings at the 89th American Thyroid Association (ATA) Annual Meeting.
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