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Rethinking ‘Rundle’s Curve’: How our Understanding of Thyroid Eye Disease (TED) Has Evolved
Our understanding of Thyroid Eye Disease (TED) has changed considerably over the last few years, driven primarily by new treatment options and research. This evolved understanding has prompted specialists in the field to reconsider the course of the disease and how to approach treatment.
Historically, TED has been considered a biphasic disease, using Rundle’s curve to show that the disease changes over time and then enters a stable phase. In this conventional time-based model, patients start with “active” or “acute” TED, where inflammatory signs and symptoms such as eye pain, swelling, proptosis and diplopia progress and may worsen. After a few years, the disease is traditionally thought to enter an “inactive” or “chronic” phase where signs, symptoms, and patient burden have been thought to be diminished.
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