Ferrari S, Fallahi P, Ruffilli I, Elia G, Ragusa F, Vita R, Benvenga S, Antonelli A
Several studies have reported an association between autoimmune thyroid disorders and other autoimmune disorders. We have focused on the prevalence of autoimmune diseases in subjects affected by Graves’ Disease (GD) with/without Graves’ ophthalmopathy (GO).
Three thousand and two hundred-nine patients with GD were prospectively evaluated regarding the appearance of other autoimmune disorders, with respect to three age (+/- 5 years) and gender, matched (3:1), control groups. We have randomly enrolled control groups from the same general population of which: 1069 subjects without thyroid disorders; 1069 patients with non-toxic multinodular goiter; and 1069 patients having autoimmune thyroiditis. Diagnoses were made by specialists according to the criteria established by the scientific societies.
We have shown a significant increase of the prevalence of autoimmune disorders in GD patients, with respect to the controls for: chronic autoimmune gastritis (CAG), vitiligo (Vit), rheumatoid arthritis, polymyalgia rheumatica (Polym), celiac disease, diabetes type 1, Sjogren disease, multiple sclerosis, systemic lupus erythematosus, sarcoidosis, systemic sclerosis, HCV-related cryoglobulinemia.
University of Pisa, Italy; University of Messina, Italy