Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Current Trends in Antithyroid Drug Treatment of Graves’ Disease
source: Expert Opinion on Pharmacotherapy
authors: Okosieme OE, Lazarus JHsummary/abstract:
Graves’ hyperthyroidism is associated with significant morbidity and mortality risk. The thionamides, methimazole, its pro-drug derivative carbimazole, and propylthiouracil, remain a cornerstone of management. Yet despite decades of use, optimal strategies for maximising treatment response and curtailing adverse effect risk remains uncertain.
We reviewed the current literature on the evidence based medical management of Graves’ disease. Specifically, we evaluated current approaches to the use of thionamides, adjunctive therapies, and potential novel agents for controlling Graves’ hyperthyroidism.
Primary medical therapy is successful in less than 50% of cases and so careful selection of patients for medical treatment based on a combination of pathological and pragmatic considerations is essential. Carbimazole or methimazole is the treatment of choice in the non-pregnant population driven by its more favourable pharmacokinetic and adverse effect profile over propylthiouracil. In pregnancy the choice of treatment is less straightforward and an approach that minimises undue fetal exposure to all thionamides should be adopted. Additional data is needed on the value of adjunctive therapies including potassium perchlorate, iodides, glucocorticoids, lithium, and cholestyramine. Novel agents directed against pathogenetic targets including TSH receptor blocking monoclonal antibodies and small molecule antagonists may hold promise for the future.
Graves’ Disease (Hyperthyroidism) in ChildrenHyperthyroidism is a disease in which th...
Substituting Potassium Iodide for Methimazole as the Treatment for Graves’ Disease During the First Trimester ...Background: To control hyperthyroidism ...
Predicting Risk of Recurrent Thyrotoxicosis Following Thionamide Withdrawal in Graves’ DiseaseBackground/Aim: Thionamides are a safe ...
Hyperthyroidism OverviewHyperthyroidism is known as overactive t...
Does Treatment of Graves’ Disease Modify The Long-Term Course of Graves’ Orbitopathy?Introduction: Graves’ orbitopathy (GO...
Drug-Like Compound Stops Thyroid Overstimulation in Early NIH StudiesResearchers at the National Institutes o...
2018 European Thyroid Association Guideline for the Management of Graves’ HyperthyroidismGraves' disease (GD) is a systemic autoi...
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.