English
Spanishwelcome to oneGRAVESvoice
- a positively charged Graves' disease and thyroid eye disease community.- join today!
- log in
Current Trends in Antithyroid Drug Treatment of Graves’ Disease
source: Expert Opinion on Pharmacotherapy
year: 2016
authors: Okosieme OE, Lazarus JH
summary/abstract:Introduction:
Graves’ hyperthyroidism is associated with significant morbidity and mortality risk. The thionamides, methimazole, its pro-drug derivative carbimazole, and propylthiouracil, remain a cornerstone of management. Yet despite decades of use, optimal strategies for maximising treatment response and curtailing adverse effect risk remains uncertain.
Areas Covered:
We reviewed the current literature on the evidence based medical management of Graves’ disease. Specifically, we evaluated current approaches to the use of thionamides, adjunctive therapies, and potential novel agents for controlling Graves’ hyperthyroidism.
Expert Opinion:
Primary medical therapy is successful in less than 50% of cases and so careful selection of patients for medical treatment based on a combination of pathological and pragmatic considerations is essential. Carbimazole or methimazole is the treatment of choice in the non-pregnant population driven by its more favourable pharmacokinetic and adverse effect profile over propylthiouracil. In pregnancy the choice of treatment is less straightforward and an approach that minimises undue fetal exposure to all thionamides should be adopted. Additional data is needed on the value of adjunctive therapies including potassium perchlorate, iodides, glucocorticoids, lithium, and cholestyramine. Novel agents directed against pathogenetic targets including TSH receptor blocking monoclonal antibodies and small molecule antagonists may hold promise for the future.
DOI: 10.1080/14656566.2016.1232388
rareRelated
-
Hyperthyroid Patients Without Graves’ Orbitopathy are not at Increased Risk of Developing Glaucoma: A Nationwi...Purpose: Graves' disease (GD) and toxic...
-
Lugol’s Solution and Other Iodide Preparations: Perspectives and Research Directions in Graves’ DiseaseLugol's solution and other preparations ...
-
Which Factors Predict the Outcome of Radioactive Iodine Therapy of Graves’ Disease?Graves’ disease is the most common cau...
-
Stress Triggers the Onset and the Recurrences of Hyperthyroidism in Patients With Graves’ DiseaseThe aim of this study was to evaluate th...
-
Treatment of Graves’ Disease – An OverviewHyperthyroidism may be defined as the ex...
-
Genetic Associations of the Thyroid Stimulating Hormone Receptor Gene With Graves’ Diseases and Graves’ ...Graves' disease (GD) is a common thyroid...
-
Radioactive Iodine Therapy vs. Antithyroid Medications for Graves’ DiseaseGraves disease is the most common cause ...
