Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Failure of Radioactive Iodine in the Treatment of Hyperthyroidism
source: Annals of Surgical Oncology
year: 2014
authors: David F Schneider, Philip E Sonderman, Michaela F Jones, Kristin A Ojomo, Herbert Chen, Juan C Jaume, Diane F Elson, Scott B Perlman, Rebecca S Sippel
summary/abstract:Background:
Persistent or recurrent hyperthyroidism after treatment with radioactive iodine (RAI) is common and many patients require either additional doses or surgery before they are cured. The purpose of this study was to identify patterns and predictors of failure of RAI in patients with hyperthyroidism.
Methods:
We conducted a retrospective review of patients treated with RAI from 2007 to 2010. Failure of RAI was defined as receipt of additional dose(s) and/or total thyroidectomy. Using a Cox proportional hazards model, we conducted univariate analysis to identify factors associated with failure of RAI. A final multivariate model was then constructed with significant (p < 0.05) variables from the univariate analysis.
Results:
Of the 325 patients analyzed, 74 patients (22.8 %) failed initial RAI treatment, 53 (71.6 %) received additional RAI, 13 (17.6 %) received additional RAI followed by surgery, and the remaining 8 (10.8 %) were cured after thyroidectomy. The percentage of patients who failed decreased in a stepwise fashion as RAI dose increased. Similarly, the incidence of failure increased as the presenting T3 level increased. Sensitivity analysis revealed that RAI doses <12.5 mCi were associated with failure while initial T3 and free T4 levels of at least 4.5 pg/mL and 2.3 ng/dL, respectively, were associated with failure. In the final multivariate analysis, higher T4 (hazard ratio [HR] 1.13; 95 % confidence interval [CI] 1.02-1.26; p = 0.02) and methimazole treatment (HR 2.55; 95 % CI 1.22-5.33; p = 0.01) were associated with failure.
DOI: 10.1245/s10434-014-3858-4
read more
myBinderRelated Content
-
The Brazilian Consensus for the Diagnosis and Treatment of Hyperthyroidism: Recommendations by the Thyroid Departmen...Introduction: Hyperthyroidism is charac...
-
Quality of Life Is Worse at 6-10 Years after Radioactive Iodine Treatment of Graves’ Disease as Compared with Anti...Background: Graves’ disease is a comm...
-
Hyperthyroidism in Children and AdolescentsWhat is the Thyroid Gland? The thyroid ...
-
Graves’ Disease Treatment for Someone in Their 20sHyperthyroidism triggered by Graves’ d...
-
The Effect of Short-Term Treatment With Lithium Carbonate on the Outcome of Radioiodine Therapy in Patients With Lon...Objective: The outcome of radioiodine t...
-
Graves’ Disease Pharmacotherapy in Women of Reproductive AgeGraves' disease is an autoimmune disorde...
-
Effect of Long-Term Continuous Methimazole Treatment of Hyperthyroidism: Comparison With RadioiodineObjective: To investigate the long-term...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Google