source: Clinical Thyroidology®

year: 2021

authors: Lilah F. Morris-Wiseman

Graves’ disease, the most common cause of hyperthyroidism, has typically been treated sequentially with antithyroid drugs (ATDs), then radioactive iodine (RAI) for patients for whom initial medical management fails. Surgery is traditionally reserved for patients with contraindications to radiation or ophthalmopathy or a need for rapid control of hyperthyroidism. Only approximately 6% of patients in the United States undergo thyroidectomy for initial management of Graves’ disease. This study aimed to compare, by first-line treatment, long-term outcomes of patients with Graves’ disease (including all-cause mortality, cardiovascular disease, atrial fibrillation, neuropsychiatric symptoms, diabetes, and hypertension), 10-year health care costs, and risk of relapse.

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