Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Post-Partum and Non-Post-Partum Relapsing Graves’ Hyperthyroidism Display Different Response to Anti-Thyroid Drugs
source: European Journal of Endocrinology / European Federation of Endocrine Societies
year: 2018
authors: Rotondi M, Capelli V, Coperchini F, Pinto S, Croce L, Tonacchera M, Chiovato L
summary/abstract:Design:
Graves’ disease (GD) patients in remission after a full course of methimazole (MMI) therapy are at risk for a relapse of hyperthyroidism during the post-partum (PP) period, but whether this relapse may display any peculiarity is still unknown. Aim of this study was to compare GD patients undergoing a relapse of hyperthyroidism either in the PP period or not.
Methods:
We retrospectively evaluated forty-three GD female patients in their childbearing age who experienced a relapse of hyperthyroidism. Eighteen of them relapsed in the PP period (i.e. within 12 months after delivery, PP group); the remaining 25 relapsed elsewhere during life (NPP group).
Results:
Age at relapse, thyroid volume, thyroid function tests, TRAb titers, smoking habit, presence and degree of orbitopathy and duration of methimazole (MMI) treatment did not differ in the two groups. However, the remission rate was much greater (79%) in the PP as compared with the NPP (32%) group (P = 0.002). A significant reduction in TRAb levels occurred at 12-month MMI treatment in the PP (F = 9.016; P = 0.001), but not in the NPP group (F = 2.433; NS). At 12 months, the PP group had significantly lower mean TRAb levels (0.6 ± 1.1 U/L and 4.5 ± 4.7 U/L in the PP and the NPP group, respectively; P = 0.029).
Conclusions:
Relapsing Graves’ hyperthyroidism in the PP period is more prone to undergo a remission after a second course of MMI treatment. In these patients, a conservative therapeutic approach is more appropriate.
DOI: 10.1530/EJE-17-1063
read more
myBinderRelated Content
-
Radioactive Iodine Therapy vs. Antithyroid Medications for Graves’ DiseaseGraves disease is the most common cause ...
-
Cancer Mortality Following Treatment for Adult HyperthyroidismContext: High-dose iodine 131 is the tr...
-
The Effect of Short-Term Treatment With Lithium Carbonate on the Outcome of Radioiodine Therapy in Patients With Lon...Objective: The outcome of radioiodine t...
-
Most Graves’ Disease Treated With Antithyroid DrugsAdults with Graves’ disease are more l...
-
Hyperthyroidism in Children and AdolescentsWhat is the Thyroid Gland? The thyroid ...
-
Double-Blind, Placebo-Controlled, Randomized Trial of Selenium in Graves HyperthyroidismContext: Supplemental selenium (Se) may...
-
Management of Endocrine Disease: Arguments for the Prolonged Use of Antithyroid Drugs in Children With Graves’...Graves' disease is an autoimmune disorde...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Facebook
Google