welcome to oneGRAVESvoice
- a positively charged Graves' disease and thyroid eye disease community.- join today!
- log in
Remission of Graves’ Disease During Anti-Thyroid Drug Therapy: Time to Reconsider the Mechanism?
source: European Journal of Endocrinology / European Federation of Endocrine Societies
year: 2006
authors: Laurberg P
summary/abstract:Therapy of Graves’ hyperthyroidism with thionamide anti-thyroid drugs is accompanied by a gradual remission of the autoimmune aberration in the majority of patients. The most likely mechanism behind this remission has been considered to be a direct immunosuppressive effect of thionamide drugs. However, a number of findings in clinical studies of patients with Graves’ disease indicate that remission is probably not caused by a special effect of thionamide drugs.
Many studies have shown that remission is linked to restoration of the euthyroid state, and that it is independent of drug dose and type. Moreover, similar remission is observed when patients become euthyroid after thyroid surgery. In an explanatory model described, it is assumed that the autoimmune aberration of Graves’ disease is often basically quit mild and self-limiting. Patients may become ill by the running of a vicious cycle of hyperthyroidism worsening the autoimmunity, and autoimmunity worsening the hyperthyroidism.
Once patients are made euthyroid by one or the other drug or by thyroid surgery, the majority of patients will gradually enter remission of the disease. The conclusion that remission is associated with restoration of the euthyroid state, and that it is not a special drug effect, highlights the importance of making and keeping patients with Graves’ disease euthyroid.
organization: Aarhus University Hospital, DenmarkDOI: 10.1530/eje.1.02295
full text source
rareRelated
-
Which Factors Predict the Outcome of Radioactive Iodine Therapy of Graves’ Disease?Graves’ disease is the most common cau...
-
The Long-Term Outcomes of Thyroid Function After Subtotal Thyroidectomy for Graves’ HyperthyroidismBackground: Surgical management of Grav...
-
Cost-Utility Analysis Comparing Radioactive Iodine, Anti-Thyroid Drugs and Total Thyroidectomy for Primary Treatment...Objective: Little data is in existence ...
-
GDATF Community Conversations: Long-Term Use of Anti-Thyroid Drugshttps://www.youtube.com/watch?v=Az5B8FU7...
-
Advances in Treatment of Active, Moderate-To-Severe Graves’ OphthalmopathyGraves' ophthalmopathy is defined as aut...
-
A Second Course of Antithyroid Drug Therapy for Recurrent Graves’ Disease: An Experience in Endocrine PracticeObjective: There are scarce reports reg...
-
Methimazole for Graves’ Disease Linked to Acute PancreatitisThe treatment of Graves' disease with th...