Graves' Orbitopathy as a Rare Disease in Europe: A European Group on Graves' Orbitopathy (EUGOGO) Position Statement - oneGRAVESvoice

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Graves’ Orbitopathy as a Rare Disease in Europe: A European Group on Graves’ Orbitopathy (EUGOGO) Position Statement

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source: Orphanet Journal of Rare Diseases

year: 2017

authors: Perros P, Hegedüs L, Bartalena L, Marcocci C, Kahaly GJ, Baldeschi L, Salvi M, Lazarus JH, Eckstein A, Pitz S, Boboridis K, Anagnostis P, Ayvaz G, Boschi A, Brix TH, Currò N, Konuk O, Marinò M, Mitchell AL, Stankovic B, Törüner FB, von Arx G, Zarković M, Wiersinga WM


Graves’ orbitopathy (GO) is an autoimmune condition, which is associated with poor clinical outcomes including impaired quality of life and socio-economic status. Current evidence suggests that the incidence of GO in Europe may be declining, however data on the prevalence of this disease are sparse. Several clinical variants of GO exist, including euthyroid GO, recently listed as a rare disease in Europe (ORPHA466682). The objective was to estimate the prevalence of GO and its clinical variants in Europe, based on available literature, and to consider whether they may potentially qualify as rare. Recent published data on the incidence of GO and Graves’ hyperthyroidism in Europe were used to estimate the prevalence of GO. The position statement was developed by a series of reviews of drafts and electronic discussions by members of the European Group on Graves’ Orbitopathy. The prevalence of GO in Europe is about 10/10,000 persons. The prevalence of other clinical variants is also low: hypothyroid GO 0.02-1.10/10,000; GO associated with dermopathy 0.15/10,000; GO associated with acropachy 0.03/10,000; asymmetrical GO 1.00-5.00/10,000; unilateral GO 0.50-1.50/10,000.

GO has a prevalence that is clearly above the threshold for rarity in Europe. However, each of its clinical variants have a low prevalence and could potentially qualify for being considered as a rare condition, providing that future research establishes that they have a distinct pathophysiology. EUGOGO considers this area of academic activity a priority.

organization: Newcastle University, UK; Royal Victoria Infirmary, UK; Odense University Hospital, Denmark; Ospedale di Circolo, Italy; University of Pisa, Italy; Johannes Gutenberg University Medical Center, Germany; Cliniques Universitaires Saint-Luc, Belgium; University of Milan, Italy; Cardiff University School of Medicine, UK; University of Duisburg-Essen, Germany; Aristotle University of Thessaloniki, Greece; Hippokration Hospital of Thessaloniki, Greece; Gazi University, Faculty of Medicine, Turkey; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Italy; Institute of Ophthalmology Clinical Centre of Serbia, Serbia; Interdisciplinary Centre for Graves' Orbitopathy, Switzerland; Academic Medical Center, Netherlands

DOI: 10.1186/s13023-017-0625-1

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