Preoperative Clinical Features of Reactivated of Graves' Orbitopathy After Orbital Decompression - oneGRAVESvoice

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Preoperative Clinical Features of Reactivated of Graves’ Orbitopathy After Orbital Decompression

key information

source: Eye

year: 2017

authors: Woo YJ, Kim JW, Yoon JS


To investigate the incidence and preoperative clinical features of reactivated Graves’ orbitopathy (GO) after orbital decompression.

This study included patients with GO who underwent orbital decompression for disfiguring proptosis and not compressive optic neuropathy and received postoperative followup care for more than 12 months. Patients who experienced active inflammatory signs within 6 months of decompression were excluded from analysis. The demographic characteristics, ophthalmic manifestations, and biochemical parameters of the patients were analyzed for association with reactivation of GO by logistic regression analysis.

Out of the 92 patients included in this study, seven (7.6%) experienced reactivation of GO after orbital decompression. The mean time interval between surgery and reactivation of GO was 36.3±14.3 weeks. Univariate logistic regression analysis identified age, existing smoking habits, and modified NOSPECS and Gorman scores as significant factors for the reactivation of GO. The results of multivariate logistic regression analysis revealed that smoking and modified NOSPECS and Gorman scores were associated with the reactivation of GO. 

Quitting smoking is important for the prevention of reactivation of GO after orbital decompression. Patients with severe symptoms, especially those with restrictive myopathy, should be carefully monitored for reactivation of GO after orbital decompression.

organization: Yonsei University College of Medicine, South Korea

DOI: 10.1038/eye.2016.304

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