Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Risk Factors for Neonatal Thyroid Dysfunction in Pregnancies Complicated by Graves’ Disease
source: European Journal of Obstetrics, Gynecology, and Reproductive Biology
year: 2014
authors: Uenaka M, Tanimura K, Tairaku S, Morioka I, Ebina Y, Yamada H
summary/abstract:Objective:
To determine the factors related to adverse pregnancy outcomes and neonatal thyroid dysfunction in pregnancies complicated by Graves’ disease.
Study Design:
Thirty-five pregnancies complicated by Graves’ disease were divided into two groups: adverse pregnancy outcome (n=15) and no adverse pregnancy outcome (n=20). Adverse pregnancy outcomes included spontaneous abortion, stillbirth, premature delivery, fetal growth restriction, and pregnancy-induced hypertension. The 31 pregnancies resulting in live births were also divided into two groups: neonatal thyroid dysfunction (n=9) and normal neonatal thyroid function (n=22). Serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), TSH-receptor antibody (TRAb), the duration of hyperthyroidism in pregnancy, doses of antithyroid medication, and the duration of maternal antithyroid medication throughout pregnancy were compared.
Results:
There were no significant differences in these factors between pregnancies with an adverse pregnancy outcome and those with no adverse pregnancy outcome. However, serum levels of FT4, TRAb, the duration of hyperthyroidism in pregnancy, the maximum daily dose of antithyroid medication, and the total dose of antithyroid medication were significantly different between pregnancies with neonatal thyroid dysfunction and those with normal neonatal thyroid function. Multivariate logistic regression analysis showed that the FT4 level in mothers was a significant factor related to the development of neonatal thyroid dysfunction (odds ratio 28.84, 95% confidence interval 1.65-503.62, p<0.05).
Conclusion:
Graves’ disease activity in women of childbearing age should be well controlled prior to conception.
DOI: 10.1016/j.ejogrb.2014.03.007
read more
myBinderRelated Content
-
Vahab Fatourechi, MDVahab Fatourechi is an endocrinologist-i...
-
2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregn...Background: Thyroid disease in pregnanc...
-
Baylor College of Medicine – Endocrine Surgery ClinicAt the Baylor College of Medicine - Endo...
-
American Thyroid Association® Satellite Symposium: Personalized Approach to Thyroid DisordersUpdate: The American Thyroid Association...
-
Double-Blind, Placebo-Controlled, Randomized Trial of Selenium in Graves HyperthyroidismContext: Supplemental selenium (Se) may...
-
The Thyroid Diet: Is There Such a Thing?Thyroid disease includes hypothyroidism,...
-
Reversible Pulmonary Hypertension and Clinical Right Heart Failure Associated With Graves’ DiseaseBackground: Heart failure is typically ...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Facebook
Google