Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Risk Factors for Neonatal Thyroid Dysfunction in Pregnancies Complicated by Graves’ Disease
source: European Journal of Obstetrics, Gynecology, and Reproductive Biology
authors: Uenaka M, Tanimura K, Tairaku S, Morioka I, Ebina Y, Yamada Hsummary/abstract:
To determine the factors related to adverse pregnancy outcomes and neonatal thyroid dysfunction in pregnancies complicated by Graves’ disease.
Thirty-five pregnancies complicated by Graves’ disease were divided into two groups: adverse pregnancy outcome (n=15) and no adverse pregnancy outcome (n=20). Adverse pregnancy outcomes included spontaneous abortion, stillbirth, premature delivery, fetal growth restriction, and pregnancy-induced hypertension. The 31 pregnancies resulting in live births were also divided into two groups: neonatal thyroid dysfunction (n=9) and normal neonatal thyroid function (n=22). Serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), TSH-receptor antibody (TRAb), the duration of hyperthyroidism in pregnancy, doses of antithyroid medication, and the duration of maternal antithyroid medication throughout pregnancy were compared.
There were no significant differences in these factors between pregnancies with an adverse pregnancy outcome and those with no adverse pregnancy outcome. However, serum levels of FT4, TRAb, the duration of hyperthyroidism in pregnancy, the maximum daily dose of antithyroid medication, and the total dose of antithyroid medication were significantly different between pregnancies with neonatal thyroid dysfunction and those with normal neonatal thyroid function. Multivariate logistic regression analysis showed that the FT4 level in mothers was a significant factor related to the development of neonatal thyroid dysfunction (odds ratio 28.84, 95% confidence interval 1.65-503.62, p<0.05).
Graves’ disease activity in women of childbearing age should be well controlled prior to conception.
Management of Neonates Born to Women With Graves’ Disease: A Cohort StudyObjective: Hyperthyroidism in neonates ...
Comparative Effectiveness of Treatment Choices for Graves’ Hyperthyroidism: A Historical Cohort StudyBackground: The optimum therapy for Gra...
Predicting Risk of Recurrent Thyrotoxicosis Following Thionamide Withdrawal in Graves’ DiseaseBackground/Aim: Thionamides are a safe ...
British Thyroid AssociationThe British Thyroid Association (BTA) is...
Treatment Choice, Satisfaction and Quality of Life in Patients With Graves’ DiseaseBackground: Thyrotoxicosis, most often ...
Graves’ Disease and PregnancyHypothyroidism During Pregnancy At firs...
Cancer Mortality Following Treatment for Adult HyperthyroidismContext: High-dose iodine 131 is the tr...
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.