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Patients who received Tepezza to treat thyroid eye disease showed improved extraocular muscle size that correlated to improved diplopia and motility, according to a presenter here. “Thyroid eye disease is known to cause inflammation, expansion and fibrosis of extraocular muscles and connective tissue of the orbit. The mechanism involves upregulation of TSHR and IGF-1R complex in orbital fibroblasts,” Edith R. Reshef, MD, of Massachusetts Eye and Ear, said at the ASOPRS Fall Scientific Symposium.
“Teprotumumab inhibits this pathway, thereby decreasing inflammatory response. The purpose of this study was to assess and quantify changes in extraocular muscle size as measured by cross-sectional area on CT in TED following teprotumumab therapy. We also sought to assess correlation between changes in extraocular muscle size and clinical outcomes of teprotumumab therapy.”
People & PlacesChildren’s Hospital Los Angeles Thyroid ClinicThe Division of Endocrinology, Diabetes ...
People & PlacesBritish Thyroid AssociationThe British Thyroid Association (BTA) is...
Evidence & EducationEffect of Long-Term Continuous Methimazole Treatment of Hyperthyroidism: Comparison With RadioiodineObjective: To investigate the long-term...
Evidence & EducationManagement of Neonates Born to Women With Graves’ Disease: A Cohort StudyObjective: Hyperthyroidism in neonates ...
Evidence & EducationGraves’ Disease and Pregnancy PlanningBoth hypothyroidism and hyperthyroidism ...
Evidence & EducationReview of the Literature and Report of a Large Series of Patients Regarding the Association of Other Autoimmune Dise...Several studies have reported an associa...
Evidence & EducationThe Effect of Short-Term Treatment With Lithium Carbonate on the Outcome of Radioiodine Therapy in Patients With Lon...Objective: The outcome of radioiodine t...
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