Changing the Face of Thyroid Eye Disease | oneGRAVESvoice

Trusted Resources: Evidence & Education

Scientific literature and patient education texts

Back to Evidence & Education / Scientific Articles

Changing the Face of Thyroid Eye Disease

key information

source: Eye

year: 2022

authors: Shoaib Ugradar, Robert A. Goldberg, Raymond S. Douglas

summary/abstract:

The history of medicine often shows us that a novel idea is not as novel as it may first appear. This is the case with thyroid-associated orbitopathy (TAO). It was first described between 1040 and 1136 AD as a systemic disorder relating enlargement of the thyroid gland to exophthalmos. This concept of a systemic condition causing exophthalmos was later readdressed in greater detail by Parry (1786) and Graves (1835). The condition is named after the latter.

Over the years, our understanding of Graves’ disease (GD) has increased. We now know that it is the most common cause of hyperthyroidism and is responsible for a myriad of signs including; a goiter, a resting tremor, tachycardia, hyperreflexia, lid lag, skin changes, and proximal myopathy. Thyroid dermopathy (pretibial myxoedema), nodular or diffuse thickening of the pretibial skin is found in 13% of patients with GD. Further, 20% of patients with dermopathy present with clubbing of the fingers and toes (thyroid acropachy). The most common extrathyroidal manifestation of GD is TAO, presenting in up to 50% of patients. It is characterized by proptosis, chemosis, diplopia and in severe cases, loss of vision.

organization: University of California, USA; Cedars-Sinai Medical Center, USA

DOI: 10.1038/s41433-022-02186-0

read more

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close